The two-door model is priced from £40,135, and first deliveries are expected to arrive in April. It's offered in the UK exclusively in AMG Line trim, meaning even the most basic models will come with a lengthy list of kit and 19in wheels as standard.
The car on show in Detroit is an E 400 4Matic, but that model will hand the range-topping spot to an AMG-engineered E 50 4Matic mild hybrid model, which is due to be unveiled during the latter half of the year.
To be launched as part of this year's extensive 50th anniversary celebrations planned for Mercedes’ AMG performance arm, the potent coupé will be among the first models to receive the German car maker’s all-new M256 in-line six-cylinder petrol engine that is set to have its debut in the S-Class.
Running a conventional turbocharger in combination with an electrically driven compressor and a 48V electrical system, the 3.0-litre unit delivers 402bhp in standard guise. However, a series of tweaks, including higher boost pressure and internal modifications, are set to yield around 450bhp for the powertrain’s application in the E 50 Coupé.