Honda is slashing production at its factory in Swindon, resulting in the potential loss of 340 jobs.
Company officials blame poor growth in Europe as the reason behind the move, with vice president Ian Howells reporting that "over the last 12 months, we haven't seen the growth we expected".
The planned cuts include 160 temporary positions, putting a sizeable dent in the 3000-strong workforce based at the Swindon factory. Cars produced at the site include the Civic, Civic Tourer, Jazz and CR-V. As of next year, the new Civic Type R will also be made at the site.
Unions have reacted to the news, with a spokesman for Unite saying it was "very bad news". As well as cutting shifts at the plant down from three to two, Honda is also moving all production to single line in order to increase efficiency.
This isn't the first time Honda has had to cut its UK workforce. The Japanese car maker announced plans in January last year to cut up to 800 jobs from its UK operations. In the end, that figure was reduced to around 550 voluntary redundancies, and 38 compulsory.
Honda is forecasting that although the Swindon plant has the capacity to build some 250,000 cars annually, it plans to make just 120,000 units this year. The site made 140,094 cars in 2013, down from 165,607 units in 2012.
The company blames continuing difficulties in mainland Europe for the drop in production, even though its sales in the UK are currently up by over four per cent on last year.
In a statement, Howells said: "With no increase forecasted for the next couple of years, we must scale our manufacturing activity accordingly.