In an interview with the BBC while speaking at Nissan's Sunderland plant for the launch of the new Qashqai, he said: "Everything has been done in the UK today considering that the UK is part of Europe. Obviously if a decision has to be made contrary to this then we will need to reconsider our strategy.
"Personally I don't think this is a most probable scenario, but if this scenario becomes real it's obviously going to be a major factor and we will need to consider what this means for us in the future."
Nissan's Sunderland plant currently employs 6500 people and produces over 500,000 cars a year, but Ghosn appeared to allay any concerns about the future of the factory.
"I'm not worried about Sunderland. Sunderland is a very competitive plant and it's a European plant based in the UK. So if anything has to change, we need to reconsider our strategy and our investments for the future."