He will take over the Lamborghini top job from 1 December, replacing Formula 1-bound Stefano Domenicali, and will remain the president of Bugatti.
The German's appointment was confirmed today in an official statement following approval by the Audi board of management, which has overall responsibility for the Lamborghini brand.
Winkelmann previously held the top job at Lamborghini from 2005 to 2016, seeing the Urus SUV into production before moving to Audi Sport.
"Stephan Winkelmann has decisively shaped the history of Lamborghini," Audi board chairman Markus Duesmann said. "No one else stands more clearly for the Lamborghini brand, and he's exactly the right person to lead this unique brand into a successful future."
Duesmann also thanked outgoing CEO Domenicali for his tenure at the Italian supercar maker, saying: "In the past four years, he has shaped the transformation of the brand and pushed it ahead. We wish him every success in his new role as CEO of Formula 1.”
"It's a great honor and pleasure for me to lead these two unique companies with their extraordinary automobiles," Winkelmann said of his new dual roles. "Our creativity in both companies is by no means finished, and the world is assured of some surprises."