Williams driver Nico Rosberg set fastest practice time for this weekend's Monaco Grand Prix.
He pipped reigning world champion Lewis Hamilton to the quickest time, the McLaren driver showing good pace on a circuit that is expected to suit his car's characteristics.
Rubens Barrichello, who had been quickest in the opening morning practice session, took third, ahead of his championship-leading Brawn team-mate Jenson Button, and Felipe Massa in the best of the Ferraris.
Red Bull recovered from its troubled morning - which saw Sebastian Vettel stop with a blown engine and Mark Webber lose time with a transmission glitch - to take sixth with Vettel, and 12th with Webber.
Robert Kubica's involvement ended when his BMW's engine erupted in a cloud of smoke and flames as he accelerated out of Sainte Devote on what should have been his first flying lap.
1 Rosberg (Williams-Toyota) 1:15.2432 Hamilton (McLaren-Mercedes) +0.2023 Barrichello (Brawn-Mercedes) +0.3474 Button (Brawn-Mercedes) +0.5315 Massa (Ferrari) 1:15.832 +0.5896 Vettel (Red Bull-Renault) +0.6047 Kovalainen (McLaren-Mercedes) +0.7418 Raikkonen (Ferrari) +0.7429 Nakajima (Williams-Toyota) +1.01710 Piquet (Renault) +1.04311 Alonso (Renault) +1.30912 Webber (Red Bull-Renault) +1.33613 Sutil (Force India-Mercedes) +1.43214 Trulli (Toyota) +1.67215 Buemi (Toro Rosso-Ferrari) +1.74016 Bourdais (Toro Rosso-Ferrari) +1.80917 Heidfeld (BMW-Sauber) +1.86618 Glock (Toyota) +1.96419 Fisichella (Force India-Mercedes) +2.26120 Kubica (BMW-Sauber) No time