The limited-edition models will be based on the current Vanquish coupé and Volante convertible. Each model will feature subtle differences tailored to reflect one of the six decades being celebrated. Aston Martin says the cars will be "instantly recognisable as Works 60th Anniversary models".
Paul Spires, commercial director of Aston Martin Works, said: "This Vanquish and its five siblings are a celebration of 60 glorious years of Aston Martin at Newport Pagnell.
"The team have created a series of cars that are forward looking and dynamic. Their anniversary accents ensure that they are certainly not a retro pastiche of our history."
Power will come from the standard Vanquish's 6.0-litre naturally aspirated V12, mated to an eight-speed automatic gearbox. The 0-60mph sprint is dispatched in a claimed 3.6sec and the Aston's top speed is reputed to be 200mph.
Bespoke metal rotary control dials formed from pistons from iconic Aston Martin engines will feature in the centre console of each Vanquish.
"We're not aware of any other manufacturer having attempted anything like this before," said Spires. "I can tell you why – it's because it's incredibly difficult."
The pistons have been sourced from engines used in the DB2/4 Mk II saloon of the 1950s, then from subsequent decades the DB5, V8 coupé, V8 Vantage X-pack, V8 Vantage supercharged and the Vanquish of the mid-2000s. Different paint and trim colours will also distinguish each version.
Each variant will include unique sill plates portraying the era the car relates to, with contrasting yellow stitching and carbonfibre adorning the interior.