Average-speed cameras are to be introduced on a major urban road for the first time.
In total, 84 cameras are to be installed on a 7.5 mile stretch of the A13 in east London, ready for use by next summer. They will operate between Canning Town and the Goresbrook interchange.
However, the speed limit will be raised from 40mph to 50mph on a section of the route once the cameras are in place.
Transport for London said it hoped the cameras would halve the number of people killed or seriously injured along the road.
It added that the collision rate on that stretch of the road has been almost a fifth higher than is typical of major roads in London.
Nearly 500 collisions, including three fatal and 34 serious accidents were recorded on this stretch of road between 2006 and 2008, with half the collisions caused by speeding, according to TfL.